Prioritization:Gene Ontology

From silico.biotoul.fr

Proximity measure

The proximity measure implemented is currently the following. It consists of computing the over-represented Gene Ontology terms in the provided set if known genes and then use the Fisher omnibus procedure to combine the p-values of the pathways in which a candidate gene is involved. See Aerts et al., 2006 for more information.

Data

The gene product associations have been downloaded from http://www.ebi.ac.uk/GOA/proteomes.html. For each Gene Ontology term, the set of genes associated is extracted and used as described in the Proximity measure section.