Prioritization:Gene Ontology
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(Created page with '== Proximity measure == The proximity measure implemented is currently the following. It consists of computing the over-represented Gene Ontology terms in the provided set if kno…')
(Created page with '== Proximity measure == The proximity measure implemented is currently the following. It consists of computing the over-represented Gene Ontology terms in the provided set if kno…')
Current revision as of 13:32, 21 January 2011
Proximity measure
The proximity measure implemented is currently the following. It consists of computing the over-represented Gene Ontology terms in the provided set if known genes and then use the Fisher omnibus procedure to combine the p-values of the pathways in which a candidate gene is involved. See Aerts et al., 2006 for more information.
Data
The gene product associations have been downloaded from http://www.ebi.ac.uk/GOA/proteomes.html. For each Gene Ontology term, the set of genes associated is extracted and used as described in the Proximity measure section.
